SHIP BY USPS: Jarrow Formulas NattoMax, Supports Healthy Circulation, 100 mg, 30 Veggie Caps

  • Purified Nattokinase Veggie Capsules
  • Clinically-Studied Cardiovascular Effects
  • 2000 FU (100 mg) Per Capsule: FU = Fibrinolytic Unit
  • Extracted From Natto Without Solvents
  • Fibrin Is Involved in Blood Clotting and Is Instrumental in Thrombosis


Product Profile

Jarrow Formulas Ribose (100% D-ribose) is for athletes and others interested in improved energy, endurance, and recovery.* Ribose is a carbohydrate found in every cell in the body. It is an important component of DNA and RNA, structures that make up our genes. Ribose is also an essential precursor to ATP, the body’s main energy source.* Research since the 1970s has continued to confirm the benefit of this compound for the heart and circulation, and recently for energy metabolism in skeletal muscles. *

Energy Production By The Cells

ATP (adenosine triphosphate) contains ribose, adenine, and three conjoined phosphate groups. Energy transfer involves the linking and unlinking of these phosphate groups. Thus, ATP provides energy when it loses a phosphate group to become ADP (adenosine diphosphate), or when it loses two phosphates to become AMP (adenosine monophosphate). Phosphate groups must be added back to AMP and ADP to replenish ATP. Creatine, another popular supplement for athletes, and the creatine phosphate system help muscles quickly replenish ATP during intense exercise by doing just that.*

Ribose Links To Energy

Under extreme stress, or in certain disease states, phosphate groups do not reattach to form ATP, and ADP is further broken down into AMP. The build-up of AMP in cells is not a stable condition, so some AMP is removed, resulting in the loss of adenine and ribose. Loss of these components in cells decreases energy storage capacity and makes it harder for the body to store and transfer energy. Cells cannot absorb ATP from blood, so each must make its own ATP. At any one time, enough ATP is stored in the body for about 10 seconds of all-out exertion - so it is imperative to keep the ADP-to-ATP energy cycle flowing smoothly. The more active the muscle, the more ATP it uses. During intense exertion, skeletal muscles quickly exhaust their ATP stores; heart muscle is particularly vulnerable to ATP shortages. As an ATP precursor, active muscles can therefore benefit from ribose supplementation.*

Ribose Improves Muscle Energy And Recovery

It should be noted that ribose is not readily available in amounts near recommended quantities from any food source. The body must make ribose from glucose through a series of complicated and energy-intensive steps. Unfortunately, this process is quite slow and may actually require days to complete. Supplemental ribose, in contrast, is immediately available to the body.* The body uses ribose energetically in three ways:

  1. Ribose can be used to produce glucose and glycogen (the storage form of carbohydrate energy). While offering the energy benefits of sugars, ribose does not affect blood sugar levels.*
  2. When oxygen is available, ribose can be converted into pyruvate, another energy source.*
  3. Most importantly, ribose is necessary for ATP production. With ribose, cells can recover rapidly from intense exertion.*

Research has shown that intense exercise causes significant adenosine phosphate decreases in skeletal muscle. These energy carriers were not fully replaced even after 72 hours of rest. This may be an important consideration in overexertion and in over-training. Research indicates that ribose supplemention may greatly reduce recovery time after intense exertion.* Indeed, ribose is the immediate precursor to PRPP (5-phosphoribosyl-1-pyrophosphate), which is the rate-limiting factor in ATP synthesis. For athletes, this is of major importance. The synthesis of the adenine/ribose component of ATP is 3-6 times faster with ribose supplementation.* Ribose is one of the necessary building blocks for the formation of ATP, the “universal” energy molecule in the body.* Physical stress can deplete ATP stores in cardiac and skeletal muscles. As the rate-limiting substrate in the synthesis of nucleotides, including ATP, ribose plays a vital role in replenishing ATP, thus, enhancing energy production, improving muscle recovery, and thus Muscle Edge.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Distinguishing Features:

  • Produced via microbial fermentation
  • Bioenergy Ribose


Jarrow Formulas NattoMax, 100mg, 30 Capsules
At a Glance:
  • Powerful fibrinolytic enzyme that supports healthy, clear blood vessels*
  • Benefits overall cardiovascular health by promoting normal blood flow*
  • Ideal for aging persons and those who want to protect circulation*
Jarrow Formulas MK-7, 60 Softgels Product Shot

Powerful fibrinolytic enzyme that supports healthy, clear blood vessels*.

Natto is a traditional Japanese food consisting of soybeans fermented with Bacillus subtilis. Its history traces back over 1,000 years, with over 200,000 tons being consumed in Japan during 2008 alone. As a food, natto is viscous and odiferous in a way that may be expected of a fermented product.

Health-wise, there are two important constituents often associated with natto 1) vitamin K2 (in the form of MK-7) and 2) nattokinase, a fibrin-dissolving enzyme. One of vitamin K's most prominent roles is assisting with blood-clotting by helping to produce clotting-factors. Nattokinase, however, is involved in the opposite process. This is sometimes the conundrum with natto.

In fact, many health practitioners rightly advise patients taking blood-thinning medication to avoid natto due to the vitamin K content. This is despite the support nattokinase may offer in helping balance clot formation and degradation.* Others with soy allergies, or those who simply have a distaste for natto, cannot access the health benefits of natto. Fortunately, Jarrow Formulas NattoMax provides purified nattokinase that is both free-from vitamin K and safe for people with soy allergies.

Blood Clotting Balance*

The biochemical cascade that leads to blood-clotting, the first step in a wound healing, is both complex and life-preserving. Without it, a minor cut could lead to an untimely demise. At the center of this process is fibrin, a fibrous protein produced by an enzyme, thrombin, which is activated when the body senses clotting is required. Upon healing the fibrin is covered over by normal tissue, while another set of proteins (e.g. plasmin) helps to dissolve the now unnecessary fibrin. This is the normal process at the site of a wound, but as we age, or under certain physiological conditions, the ability to dissolve fibrin tends to fall out of balance with the ability to create fibrin.

When fibrin accumulates in blood vessels, blood begins to flow less freely. This can reduce oxygen transport to heart and brain tissue, resulting in suboptimal function. Meanwhile, the excess fibrin can make blood vessels less pliable and lead to elevated blood pressure. Nattokinase helps to maintain proper blood viscosity, fibrin levels and healthy circulation, all effects that draw support from research conducted at the National Cardiovascular Center in Japan.*

Nattokinase and Circulation

Nattokinase is believed to do a number of things in promoting circulatory health.* First, it acts as a natural fibrinolytic (clot-dissolving) enzyme that helps to support the body's ability to regulate fibrin.* In fact, this is why nattokinase is measured in terms of fibrinolytic units (FU). And some research suggests that nattokinase is more effective than the body's own enzyme, plasmin, for this purpose.

Second, nattokinase appears to support normal levels of plasminogen activator inhibitor 1 (PAI-1). High levels of PAI-1 can negatively impact fibrin degradation by reducing the plasminogen levels that are critical to the production of plasmin. By maintaining normal levels of PAI-1, nattokinase supports the body's own fibrin-dissolving mechanisms.*

Enzyme Digestion

Ingesting an enzyme raises an interesting question, "if an enzyme is merely a protein won't it be digested and inactivated in the intestines?" There's little doubt that some of the nattokinase is broken-down into smaller protein fragments and amino acids, but it seems that a significant portion is absorbed, fully functional.

Yet even more interesting is research suggesting that fragments of nattokinase, generated upon digestion, have circulatory-health activity too. This does not come as a huge surprise since other food-source protein fragments, such as those from sesame and milk , possess biological activity. But what may be less expected is that fragments of nattokinase appear to possess distinct and complementary effects to that of the whole enzyme. For instance, researchers found that nattokinase fragments interacted with angiotensin II, a peptide hormone that helps regulate blood pressure via action on other enzymes such as renin and acetycholineesterase. Whole nattokinase does not do this. This means that the action of digestion on nattokinase may actually be beneficial, not detrimental.


If you have a medical condition (especially bleeding disorders), are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications (especially blood-thinning or blood-clotting medications), consult your health care practitioner before using this product.

About Jarrow Formulas

Jarrow Formulas' complete line of over 350 nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Customers can be assured of purity, value and potency when choosing these products.

What's in the Box

Jarrow Formulas NattoMax, 100mg, 30 Capsules.

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